Pharmacokinetics & Biodistribution

Pharmacokinetics (PK) research is essential for deciphering the biological pathways that translate drug administration into pharmacological effects. Factors such as formulation, metabolic profile, and receptor sensitivity collectively dictate therapeutic outcomes.

Understanding inter-individual variations—specifically in absorption, enzyme activity, and protein binding—is crucial, as these determine the drug concentration at the site of action and explain divergent clinical responses.

We provide accurate and reliable analytical results for biopharmaceuticals, clinical compounds and food, backed by advanced high-resolution mass spectrometry and expert support. Our services offer fully customized, end-to-end pharmacokinetic (PK) support across all preclinical and clinical phases, ensuring compliance with your specific regulatory and research needs.

Small and Large Molecules
We develop customized study designs to systematically monitor in vivo ADME and kinetic profiles.

Cell and Gene Therapies
We design optimized analytical strategies based on modality characterization. By evaluating organ distribution and persistence, we provide pivotal scientific evidence to support safety profiles and therapeutic durability.

Service items

• PK/TK Analysis
  Application of LC-MS/MS for drug concentration monitoring and pharmacokinetic/toxicokinetic parameter calculation of small molecules, peptides, and metabolites.
• Multi-Omics Translational Research
  Leveraging high-resolution mass spectrometry for proteomics and metabolomics profiling to provide deep insights into the biodistribution and biological impact of emerging therapies, such as exosomes and cell therapies.
• Biodistribution Analysis
  Assessing the organ distribution and persistence of cell and gene therapy (CGT) products within biological systems through genetic testing (qPCR/ddPCR), immunohistochemistry (IHC), and in vivo imaging systems (IVIS).